Thursday, October 11, 2012

BOTOX Trial for Hay Fever and Asthma Treatment




As you probably know, the introduction of Botox injections has revolutionized cosmetic industry. But Botox is not just the world's most famous wrinkle-buster – it has been rather used to treat more than 50 different medical conditions like migraines, incontinence, excessive sweating or ophthalmological disorders!

Now Australian investigators from Melbourne – under the leadership of professor Philip Bardin – are going to conduct a world-first randomized placebo-controlled trial of a Botox gel that could potentially provide relief to people with hay fever (allergic rhinitis). Under the trial, a Botox gel will be applied to the nose to hopefully give hay fever sufferers relief from sneezing, itchy eyes and runny noses for up to three months.

For the purpose of this trial, the Botox molecule has been re-engineered to be able to penetrate through the lining of the nose. Professor Bardin said preliminary studies had shown that botulinum toxin-A offered relief from allergic rhinitis by blocking nerve endings in the nasal passage and potentially blocking some of the chemicals released by the nerve endings which play a large role in causing symptoms. This reduced inflammation and halted the onset of symptoms.

Previously, the same team had very promising results applying Botox into the voicebox as a treatment for severe asthma.





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